Charlie Guthmann

Data Innovation & AI Lab. Effective altruism, quant trading, AI and econometrics research. Chicago → Philadelphia.

Research

Philly Venue Landscape — Mapping 4,882 event sources across Philadelphia
Caption Validation Pilot — LLM caption validation: 50 images x 3 models (GPT-4o-mini, 4o, 5.2)
Pathway Labeling Showcase — 3-signal comparison: Gemini vs Jaccard vs PMC caption
PMC Caption Audit — Validating Gemini pathway labels against figure captions
Pathway Alignment — Mapping 8,349 extracted pathway names to KEGG/WikiPathways
Pathway Analyzer — 49k pathway diagrams → 1.3M gene interactions via Gemini 3
GWAS Researcher Prestige — Matching author affiliations to QS 2005 rankings
GWAS Analysis — Genome-wide association studies
Gene Panel Analysis — Serendipity project statistical results
Patent Data — Disease and gene patent analysis
Orange Book Extension Plan — Valuing GWAS spillovers with FDA & market data
Orange Book Progress — Current status & learnings (Days 1-4)

charliejguthmann [at] gmail [dot] com