We construct a "landscape model" mapping gene-disease relationships through biological pathways and disease taxonomies—enabling rigorous measurement of how scientific knowledge propagates.
GWAS Discovery
Gene A linked to Disease X
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Pathway Network
Biological connections to related genes
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Spillover Impact
Innovation in related gene-disease pairs
Implication for NLM
This framework provides evidence-based tools to assess the true return on genomic research investments—capturing value that traditional metrics miss.